LAPaL was launched in May 2021 as the first go-to resource for information on long-acting technologies patents and licences.
As of May 2023, it comprises 10 long-acting platform technologies with many potential applications in the fields of HIV prevention and treatment, hepatitis B treatment, malaria treatment, type 2 diabetes and metabolic disorders management, pain management and contraception, among other applications.
Three of these technologies was recently licensed to MPP to ensure that equitable access is granted to the persons needing them in low- and middle-income countries.
In 2023, and through a collaboration with the Center of Excellence of Long Acting Therapeutics and the Long-Acting/Extended Release Antiretroviral Research Resource Program, a new section was added to LAPaL, with 10 compounds with long half-life or that could be formulated in a manner that enables extended release. We are also collaborating with major initiatives and groups, such as AVAC, to synergise efforts and support the global community to deliver effectively in the HIV prevention space.
Additionally, a visualisation tool (Landscape) is being tested to benchmark a selection of investigated and approved long-acting compounds in the HIV and TB fields and the related clinical trials. It provides information on the clinical trials pipeline of a set of compounds and filing data for the most advances products. You can browse the beta version of the landscape and provide us with your feedback to improve it!
We would like to acknowledge the support, technical assistance and resources sharing from the following organisations and groups:
We would also like to thank the innovators who have kindly contributed to the database and to the users providing their valuable feedback.
Scientific publications and reviews, reports, infographics, blog posts, interviews, etc. We love reading the latest news and publications from the long-acting world.
Please send us your citation so we can add it to the reading roll.
We have listed some resources from the long-acting space that you could find useful:
If you think another resource should be listed below, please let us know!
Thanks for your collaboration.
The Long-Acting technologies patents and licences database LAPaL is a free online resource coordinated by the Medicines Patent Pool.
It provides information on technical features and intellectual property status of selected long-acting therapeutics and their potential applications, in particular, in the fields of HIV, viral hepatitis, tuberculosis and malaria.
In 2023, ten compounds used or investigated as long-acting formulations were added to LAPaL, as well as a visual landscape of clinical trials advances and regulatory status of selected compounds with LA applications. This work is done in collaboration with LEAP and the University of Liverpool's CELT.
For each technology, innovators are invited to review a set of access principles that will reinforce access opportunities throughout a technology development, manufacturing, and distribution life cycle.
These access principles set the ground for reinforced collaboration for long-acting product candidates’ development, encourage sharing of technical data to achieve public health benefits and support the establishment of appropriate strategies for timely and affordable access in low and middle-income countries, including through licensing.
Innovators may show their commitment level by indicating their agreement to each of these principles. This commitment is shown as colour variations on their technology card in LAPaL indicating that the innovator agrees, does not agree, or agrees under certain conditions to the proposed access principles.
LAPaL includes information on selected long-acting technologies and compounds with LA potential and an overview of their intellectual property landscape.
The data are carefully curated and where possible, the data are backed by scientific publications and insights found in the public domain or provided by the innovators as factsheets, corporate presentations, or other media of interest to LAPaL audience.
In 2023, a visualisation dashboard was added to LAPaL, to help users navigate a set of long-acting compounds clinical trials landscape and regulatory filings information for a subset of these.
The Long-Acting technologies patents and licences database LAPaL is a collaborative platform, where publicly available information is gathered by MPP with the support of the innovators. The information is then curated, and innovators are invited to fact-check and update their technologies profiles.
All information related to intellectual property is curated by a dedicated IP-specialists team at MPP.
Sources for data collection for compounds and manufacturing sections include published scientific papers, supplemented with information from online data repositories such as:
For the clinical trials and studies information and updates, the main sources of information are:
with additional information sourced from the trial sponsors website and any associated publications.
LAPaL is a non-exhaustive source of information on long-acting platform technologies and compounds in a disease-agnostic approach. When a platform technology is being developed in association with a therapeutic agent or agents, these are listed as potential applications.
Initially, LAPaL is focusing on long-acting technologies that have foreseen applications with potential impact for global health. The scope is therefore wide, although initially prioritising technologies with applications to relieve health conditions in line with MPP and Unitaid historic mandates: HIV, tuberculosis, hepatitis and malaria prevention and treatment. A particular attention is given to multi-purpose technologies targeting for example HIV and another viral infection or HIV and pregnancy. Potential applications to other medicines and other health areas are also listed.
LAPaL includes information on long-acting platform technologies and compounds at any stage of development.
As a long-acting technology developer, you can submit your technology to LAPaL, or we will reach out to you to fact-check your technology profile that we would have put together using publicly available information. You will have the opportunity to provide information about the technology properties, development stage, potential applications and the most relevant patents and licences.
If you are curious about long-acting therapeutics, LAPaL might be a go-to resource for you, whether you are a tech innovator or not. All LAPaL users are welcome to contribute to this collaborative tool. We will be happy to hear your thoughts and discuss your proposals to help us improve the database content, looks and features.
A long-acting technology with potential public health benefit might end up in LAPaL either through direct submission by the innovator or through MPP curation and reach out to innovator for support in submission. In both cases, we envisage a close collaboration with the innovator to ensure they are associated to all relevant updates to their technologies.
In some cases, we may identify a particularly important technology from a public health perspective, but we may face challenges in involving the innovators in the data collection and updating process. If this occurs, we will upload the technology profile and flag it as “MPP-sourced” until the innovator fact-checks it.
If you would like to submit your long-acting technology to LAPaL, you will need to create a user account that will be associated with that technology. You will then be guided through a twenty questions online form to provide information related to:
To start the submission process and creating a technology card, click on “submit a technology” tab and create an account or use an existing account. If you need to reset your password, please check the spam folder in case the verification email is delayed.
There is no submission process for compounds. These are added by a team of researchers from University of Liverpool.
In case you notice any error or discrepancy, please reach out to us to correct it. Thanks for that!
LAPaL is coordinated by the Medicines Patent Pool (MPP), a United Nations-backed public health organisation working to increase access to, and facilitate the development of, life-saving medicines for low- and middle-income countries. Funding for this database as well as for MPP’s work in the long-acting space is secured through a Unitaid grant.
The section specific to long-acting compounds is curated by a team of experts from the Center of Excellence of Long-acting Therapeutics (CELT) based at the University of Liverpool. They have also developed the landscape visualisation tool to browse LA compounds development status and regulatory filing status.
MPP would like to acknowledge the technical support from:
Furthermore, we are grateful to all the innovators and stakeholders who have provided data and advice to enrich the repository and who are putting in their best efforts to advance the long-acting technologies pipeline with access considerations as an integral part of the work.
The platform was built by MobileThinking in Geneva.
Every technology has its own “technology card” with the name of the technology and its main developer, as well as an illustration. The “Summary” button allows for a shortcut to an overview of the technology main features as well as to the Access Principles commitment from the innovator.
For a more detailed view, the “see more” button will take the user to a dedicated page with various tabs related to the technology. These tabs cover:
LAPaL provides a non-exhaustive list of patents related to the technology and potential application products when the latter are available in MedsPaL. The information about these patents and licences are shown in LAPaL as a summary table indicating whether patents relate to the technology or to its potential applications.
For each patent family, an abstract is provided, and the country patent applications are listed. LAPaL patent descriptions may be reformulated by MPP and may not be the official descriptions appearing in patent documents.
LAPaL builds on MPP’s experience in mapping patents on key health technologies through MedsPaL. MedsPaL is MPP’s patents and licences database for medicines. It provides information on the patent and licensing status of patented essential medicines in low- and middle-income countries.
LAPaL administrators use the information provided by the innovators on the most relevant patents and licences related to their technology (one representative publication per family). This information is used to map equivalent patents and patent applications worldwide as well as their latest status.
When a technology is “MPP sourced”, the search for relevant patents will be performed in-house.
When potential applications with APIs are listed by the innovators, a second list is created with the most relevant patents and licences related to this API.
Moreover, when a licence agreement related to the technology or the potential APIs to be potentially used with it has been signed, this is highlighted and a link to the licence is provided.
If the API is already included in MedsPaL, the patent data for this API will be retrieved from MedsPaL.
An important difference with the patent and licensing information provided in MedsPaL, is that it not only includes information for low and middle-income countries as defined by the World Bank, for which patent data could be obtained, but also high-level information on high-income countries status.
LAPaL can be browsed by clicking on a given “technology card” or "compound card".
If you are looking for a specific technology or product, you can use the LAPaL search engine by technology name by developer/innovator or by potential matching APIs (Active Pharmaceutical Ingredients).
Another possibility is to select various options in the drop-down menus of the technology characteristics on the left bar (these use the "OR" logic).
For a more comfortable user experience, a keywords pool tab is shown at the top of the screen, with all ticked search words, to fine-tune search criteria.
In 2022, a new search filter was added for APIs search. The categorisation of APIs is based on WHO Collaborating Centre for Drug Statistics Methodology. Therefore, some APIs appear more than one time (as part of more than one family of agents).
In 2023, a landscape tool (beta version) was added to LAPaL to browse the status of listed compounds development status.
In each technology and compound card, there is an export button that will generate a PDF for the given technology/compound. You also have the possibility to print the tech card, but please be mindful of the climate.
We will be happy to receive suggestions and enquiries related to LAPaL or the long-acting project more generally. Please use the contact form on the top bar or write to
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Users should NOT consider LAPaL a complete and authoritative source of information. The patents landscape for each technology is not intended as a ‘freedom-to-operate’ analysis. LAPaL only provides a snapshot at a point in time, based on the information available to MPP. The technical information provided is based on publicly available information, should not be considered as exhaustive and may have lapsed.
All MedsPaL disclaimers apply to LAPaL patent information. In particular, we do not accept any legal responsibility for the accuracy of data. We do not guarantee it is complete, up to date or fit for specific purposes. Users should undertake additional country searches and legal analysis before making any procurement or business decision based on the patent landscape.
A full understanding of the patent situation in any country, for a specific technology or agent, requires additional information and analysis not provided in LAPaL. This includes an analysis of the specific claims of a national/regional patent application or granted patent. Users should also consider whether the country is a Least Developed Country (LDC) and may benefit from the transition period provided by the World Trade Organization TRIPS Agreement, or whether the country is making use of any of the other flexibilities available under national or international regulations.